i7 5820K @ 4.25GHz | EVGA GTX 1080 SC | Gigabyte GA-X99-UD4 | Corsair DDR4 3000 32GB | Corsair HX 750W
SSDs: Intel 660p M.2 2TB, 3x Samsung Evo 1TB | Startech PCIe 4x USB 3.0 | Startech PCIe 2x USB C 3.1 gen2
It’s usually an issue if too much bandwidth through one USB controller. Try moving around some of your USB devices to different ports. Plug anything that doesn’t need USB 3.0 into USB 2.0 ports if possible, or unplug things you aren’t using right now.