It has happened in Pavlov VR as well as in Space Junkies at some point while gaming - only restarting or disconnecting and reconnecting the Rift switched the right and left audio channels back to normal. Is this a known issue?
Sorry, this is more of a community help forum than the Oculus direct. Please contact them at https://tickets.oculusvr.com/hc/en-us/requests/new. It sounds more like you might be having a USB issue though - have you tried a different port or switching to the front or back side of the computer? Sometimes a whole USB controller could be messing up. Also would be something wrong with your motherboard failing such as the sound controller or a bad driver update. I'm guess with out more information though.